Artifact farming in Genshin Impact is essential for strengthening your characters and keeping your builds competitive across late-game content. While Domains offer the best chance at high-quality 5-star sets, open-world farming is vital for gathering artifact fodder—especially if you’re investing in upgrading those hard-earned 5-star pieces. Fontaine, the Hydro nation introduced in Version 4.0, is packed with artifact-rich locations that can be looted every 24 hours, making it a great region to add to your daily or weekly farming route.
In this guide, we’ll cover the most efficient Fontaine artifact farming routes, including the New Fontaine Research Institute, Central Laboratory Ruins, and other key locations like the Institute of Natural Philosophy and Faded Castle. Whether you’re a veteran player looking to stockpile fodder or a newcomer seeking to power up your characters, this route has you covered.
Table of Contents
- 1 Why Farm Artifacts in Fontaine?
- 2 Best Fontaine Artifact Routes (Full Walkthrough)
- 2.1 🧪 1. New Fontaine Research Institute Route
- 2.2 🧪 2. Central Laboratory Ruins Route
- 2.3 🧪 3. Mont Esus East Route
- 2.4 🧪 4. Liffey Region – Statue of the Seven Route
- 2.5 🧪 5. Institute of Natural Philosophy (Court of Fontaine)
- 2.6 🧪 6. Orthant of Persona (Morte Region)
- 2.7 🧪 7. Faded Castle (Nostoi Region)
- 3 Optimize Your Farming Efficiency
- 4 Need Help? GladiatorBoost Has You Covered
- 5 Final Thoughts
Why Farm Artifacts in Fontaine?

While artifact Domains are your primary source for full sets, overworld artifact spots provide reliable sources of 1- to 3-star artifacts—perfect for leveling your main gear. Fontaine’s overworld spots are easy to access and can yield upwards of 40+ artifacts per daily run, often taking less than 15 minutes to complete.
Best Fontaine Artifact Routes (Full Walkthrough)
🧪 1. New Fontaine Research Institute Route
This is one of the densest artifact routes in the region and an ideal place to start.
Step-by-step:
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Teleport to the topmost waypoint in the Research Institute.
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Head left toward some crates—two quick artifacts here.
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Continue left and climb the tower in the distance. Enter through the window, and search each floor for glowing spots.
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Exit from the bottom, glide down to the road, and destroy the nearby tubes to reveal artifact spots.
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Move up the hill to find more tubes and investigation points—expect 4 more artifacts here.
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Teleport to the eastern waypoint, move right toward the shoreline, and find crates under a tree.
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Continue along the coast to grab two more boxes with artifacts.
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Turn left inland, climb the stairs to the golden wheel, and collect a hidden artifact.
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Behind the wheel, glide to another box below the cliffs for more loot, then cross to a final crate nearby.
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Finally, glide down to the beach, where a couple of boxes near the shore hold more artifacts and mora.
Estimated Time: ~5 minutes
Artifacts Collected: 10–15+
🧪 2. Central Laboratory Ruins Route
This route offers a fast and compact area filled with glowing investigation points.
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Teleport to the waypoint north of the ruins.
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Glide down and enter the ruins through the bottom entrance.
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Run through the halls and interact with all glowing points, especially around tables and collapsed machinery.
Estimated Time: ~3 minutes
Artifacts Collected: 7–10
🧪 3. Mont Esus East Route
A short but easy grab.
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Teleport to Mont Esus East waypoint.
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Two artifact boxes are directly ahead, by the road.
Estimated Time: ~1 minute
Artifacts Collected: 2
🧪 4. Liffey Region – Statue of the Seven Route
Quick and artifact-rich, this route is great for daily runs.
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Teleport to the Statue of the Seven.
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Turn right and jump down the ledge—look for a golden wheel on the ground.
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Enter the building and check bookshelves and tables for more artifacts.
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Past Desmos, the director NPC, you’ll find one more wheel for an artifact check.
Estimated Time: ~4 minutes
Artifacts Collected: 5–7
🧪 5. Institute of Natural Philosophy (Court of Fontaine)
An underwater zone that becomes available after completing the Aqueous Tidemarks World Quest.
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Teleport to the waypoint north of the Institute.
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Check the right for a crate with artifacts, then head into the Institute.
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Follow the path left toward bookshelves, then down the stairs.
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Pass the Ruin Hunter to find more bookshelves.
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Climb to the second floor to grab four more artifact points.
Estimated Time: ~4–5 minutes
Artifacts Collected: 8–10
🧪 6. Orthant of Persona (Morte Region)
Only available after completing In the Wake of Narcissus.
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Teleport to the underwater waypoint south of the Tower of Ipsissimus.
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Swim into the ruins and interact with bookcases, drawers, and tables as you explore the Orthant.
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Look for glowing spots around the main corridor and deeper chambers.
Estimated Time: ~5 minutes
Artifacts Collected: 7–10
🧪 7. Faded Castle (Nostoi Region)
Unlocks after The Shadow Over Petrichor World Quest.
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Start at the central teleport waypoint.
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Turn right for the first investigation table.
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Go down the stairs and check tables and floors for more artifacts.
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Proceed toward the music room, where more investigation points await.
Estimated Time: ~4 minutes
Artifacts Collected: 6–8
Optimize Your Farming Efficiency
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Use Anemo characters like Sayu, Wanderer, or Kaedehara Kazuha for faster movement and stamina conservation.
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Equip characters with gadget slots like the Treasure Compass if you’re exploring side areas for additional loot.
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Make this route part of your weekly farming routine to ensure a steady influx of artifact fodder for leveling.
Need Help? GladiatorBoost Has You Covered
Struggling to manage your farming routine or optimize your artifact builds? At GladiatorBoost’s Genshin Impact Farming Services, expert players are ready to help you maximize your time and efficiency. Whether you need assistance farming artifacts, domains, or weekly bosses, GladiatorBoost offers:
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Artifact and resource farming
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Team optimization and build advice
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Custom orders for your favorite characters
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Account progression support
Let GladiatorBoost handle the grind while you enjoy exploring Teyvat on your own terms.
Final Thoughts
Fontaine offers some of the best open-world artifact farming opportunities in Genshin Impact, especially when you’re low on resin and need fodder to upgrade key pieces. With this route, you can easily collect 40+ artifacts in less than 15 minutes—a major win for any player looking to stay ahead in endgame content.
Make the most of your farming runs, and don’t forget to revisit these locations every day to keep your artifact stash stocked and your characters powered up.
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